Involved researchers: Nicolas TAULIER, Wladimir URBACH
Sono activable drug delivery systems use ultrasound technology to initiate the release of therapeutic drugs at precise locations within the body. These drug delivery systems represent an advancement in the field of medicine, offering tailored treatment options that enhance efficacy while prioritizing patient safety and offers several significant advantages such as:
- Targeted Delivery: By utilizing focused ultrasound waves, these systems can concentrate treatment on specific anatomical areas, such as tumors or inflamed tissues. This localized delivery minimizes unintended exposure to surrounding healthy tissues, thereby reducing the risk of side effects commonly associated with systemic drug administration.
- Controlled Release: Sono activable systems allow for control over the timing and dosage of drug release. Healthcare providers can adjust the ultrasound intensity and duration to optimize the efficacy of the drug, ensuring that it is delivered when and where it is most needed, which can significantly enhance patient outcomes.
- Enhanced Penetration: Ultrasound has been shown to increase the permeability of cellular membranes, facilitating greater drug absorption into target cells. This enhanced penetration is particularly valuable for larger molecules or those that typically face barriers to entry, thus improving the overall effectiveness and performance of the therapy.
- Reduced Systemic Toxicity: One of the most compelling benefits of this targeted approach is the reduction in overall drug exposure throughout the body. By delivering a higher concentration of the drug directly to the affected area, the likelihood of systemic toxic effects is diminished. This targeted strategy not only increases drug efficacy but also enhances patient safety.
- Real-Time Monitoring: The integration of ultrasound imaging technology allows for continuous, real-time monitoring of the drug delivery process. Clinicians can visualize the treatment area and make immediate adjustments as necessary, thereby improving the precision of the therapy and adapting to the patient’s response.
- Versatility: Sono activable drug delivery systems can be utilized for a wide array of pharmaceutical agents and therapeutic modalities. This includes small molecules, proteins, and even advanced gene therapies, making the method applicable across diverse medical conditions and treatment objectives.
- BBB on a chip
- Ultrasound trigggered BBB opening
- Sono-activable drug carriers
