Clinical assessment of bone strength from ultrasonic guided waves measured in axial transmission
Project duration : 3 years
Starting March 2014
- Dr. Emmanuel Bossy, Institut Langevin, Paris, France
- Prof. Christian Roux, INSERM, U 1153, Rheumatology Department, Cochin Hospital, Paris Descartes University, Paris, France
We aim at developing new ultrasound-based biomarkers of cortical bone to enhance fracture risk prediction in osteoporosis. Our approach is based on the original concept of measuring ultrasonic guided waves to yield estimates of strength-related structural and material properties of cortical bone. The project includes bio-engineering and instrumentation aspects developed by the principal applicant’s group, supported by both basic (Dr Emmanuel Bossy, Institut Langevin) and clinical research (Professeur Christian Roux, Inserm U 1153).
The main steps are:
- Modeling wave propagation in cortical bone
Validation of the biomarkers using multi-modal ex vivo experiments.
A clinical study in which the performance of the biomarkers will be assessed.