Type de stage :
- Stage de Master 2 ou dernière année d’école d’ingénieur
Période et durée du stage :
- Premier semestre 2017, durée minimale de 6 mois.
Contexte :
Dynamic contrast-enhanced ultrasound (DCE-US) is a promising imaging modality with a growing number of clinical applications, such as anti-angiogenic therapy assessment and hepatic lesion classification. In order to compare data at different dates or from different groups, for instance to follow the effects of a therapy, it is necessary to develop consistent and robust techniques to evaluate the microvascular distribution in lesions and tumours. DCE-US sequences are acquired with 2D probes which is a strong limitation to investigate tumors which are complex and heterogeneous 3D tissues.:. Motion, due to respiration or probe movements, is inevitable and is a major cause of variability in the estimation of flow parameters in lesions and tumors even if techniques like gating or registration [1] have been developed.
However 3D DCE-US acquisitions with 3D probes is emerging, and dedicated registration techniques (due to the multiplicative nature of US noise [2], the amount of data…) have to be developed to effectively investigate tumors with those 3D+t acquisitions.
This project is a collaboration with Forsberg Flemming (Thomas Jefferson University, Philadelphia, US) who acquired the data.
Objectifs :
Set up and validate a registration method dedicated to 3D DCE-US sequences
Mission(s) :
- Bibliography study
- Develop and evaluate this new registration method based on our past experience of 2D DCE-US registration and analysis,
Compétences requises :
- Image processing, applied mathematics, optimization, ultrasound, English, Matlab, C/C++.
Bibliographie :
[1] G. Barrois, A. Coron, O. Lucidarme, and S. L. Bridal, “Automatic motion estimation using flow parameters for dynamic contrast-enhanced ultrasound.,” Phys. Med. Biol., vol. 60, no. 6, pp. 2117–2133, 2015. [2] G. Barrois, A. Coron, T. Payen, A. Dizeux, and L. Bridal, “A Multiplicative Model for Improving Microvascular Flow Estimation in Dynamic Contrast-Enhanced Ultrasound (DCE-US): Theory and Experimental Validation,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 60, no. 11, pp. 2284–2294, 2013.Lieu de déroulement du stage :
Laboratoire d’Imagerie Biomédicale, 15 rue de l’Ecole de Médecine, 75006 Paris
Rémunération :
- Gratifications de stage (~520 €). .
